Preclinical Rethinking Webinar | Replication of null results: absence of evidence or evidence of absence?

In the fourth session, Dr. Samuel Pawel (Epidemiology, Biostatistics and Prevention Institute, University of Zurich) will explore the concept of replicating null findings and present methods for evaluating their replication.

Course Description

Preclinical research aims to develop potential therapies and to translate scientific discoveries into clinical applications for patients. This process requires rigorous hypothesis testing and experimentation in model systems to confirm treatment efficacy and safety before advancing to clinical trials. However, translational failures where clinical trials fail to replicate promising preclinical results are common, creating a significant gap with medical, economic, social, and ethical consequences.

Concerns about the low success rate of translating preclinical research into effective clinical interventions has grown within the biomedical community.

Learning Objectives

This seminar series, part of the DECIDE II project, features nine expert speakers across seven sessions, addressing strategies to enhance the robustness and efficiency of preclinical research, striving to close the translational gap and to strengthen the community.

If you were unable to attend a webinar session, you can access the slides and the recorded session here.

Target Audience

• Research fellows, early career researcher (postdocs, PhDs, students)

• Members of BIH, CHA, BUA and external institutions (academia, industry, other organizations)

Participation Requirements
None. 

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